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Judul Mathematical study of feedback inhibition effects on the dynamics of metabolites on the central metabolism of a yeast cell: a combination of kinetic model and metabolic control analysis
Pengarang Kasbawati
Agnes
Anisa Kalondeng & Sulfahri
EDISI Journal Biotechnology & Biotechnological Equipment
Penerbitan https://www.tandfonline.com/action/journalInformation?journalCode=tbeq20, 2019
Deskripsi Fisik 2 hlm.
Subjek Yeast cell
fermentation system
feedback inhibition
kinetic modelling
stability theory
metabolic control analysis
metabolite dynamics
Abstrak The fermentation system is a metabolic system that can be considered as a complex system, since it involves metabolites linked by different reactions. Some outputs of the reaction act as input in the other reactions and they control the behaviour of the system. Glucose as the main carbon source of the yeast cells plays an important role in the cell’s reproduction cycle and product synthesis. Glucose promotes negative feedback to some reactions in the central metabolism of the yeast cell. In this paper we mathematically study the effects of the negative feedback (inhibition) by glucose and other metabolites on the dynamics of the fermentation system. We also study the sensitivity of the flux in the presence of inhibition. We found that high inhibition by glucose affects the concentration of acetyl-CoA, which will lead to the respiration pathway of the yeast cells. High inhibition by acetaldehyde affects the concentration of all metabolites, including the maximal concentration of ethanol. Based on the metabolic control analysis results, we found that glucose can be considered as the external regulating point in increasing the flux of ethanol. Although glucose acts as a negative feedback, it can also be used to promote certain processes in the metabolic pathway since it gives the highest positive control in increasing the flux of ethanol as the desired product. For the internal regulation point, the maximal concentration of ethanol can be increased significantly by regulating the maximal activity of alcohol dehydrogenase and acetaldehyde dehydrogenase simultaneously.
Bahasa Inggris
Bentuk Karya Bukan fiksi atau tidak didefinisikan
Target Pembaca Tidak diketahui / tidak ditentukan

 
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008 191104###########################0#eng##
035 # # $a 0010-1119000042
100 0 # $a Kasbawati
245 1 # $a Mathematical study of feedback inhibition effects on the dynamics of metabolites on the central metabolism of a yeast cell: a combination of kinetic model and metabolic control analysis
250 # # $a Journal Biotechnology & Biotechnological Equipment
260 # # :$b https://www.tandfonline.com/action/journalInformation?journalCode=tbeq20,$c 2019
300 # # $a 2 hlm.
520 # # $a The fermentation system is a metabolic system that can be considered as a complex system, since it involves metabolites linked by different reactions. Some outputs of the reaction act as input in the other reactions and they control the behaviour of the system. Glucose as the main carbon source of the yeast cells plays an important role in the cell’s reproduction cycle and product synthesis. Glucose promotes negative feedback to some reactions in the central metabolism of the yeast cell. In this paper we mathematically study the effects of the negative feedback (inhibition) by glucose and other metabolites on the dynamics of the fermentation system. We also study the sensitivity of the flux in the presence of inhibition. We found that high inhibition by glucose affects the concentration of acetyl-CoA, which will lead to the respiration pathway of the yeast cells. High inhibition by acetaldehyde affects the concentration of all metabolites, including the maximal concentration of ethanol. Based on the metabolic control analysis results, we found that glucose can be considered as the external regulating point in increasing the flux of ethanol. Although glucose acts as a negative feedback, it can also be used to promote certain processes in the metabolic pathway since it gives the highest positive control in increasing the flux of ethanol as the desired product. For the internal regulation point, the maximal concentration of ethanol can be increased significantly by regulating the maximal activity of alcohol dehydrogenase and acetaldehyde dehydrogenase simultaneously.
650 # # $a feedback inhibition
650 # # $a fermentation system
650 # # $a kinetic modelling
650 # # $a metabolic control analysis
650 # # $a metabolite dynamics
650 # # $a stability theory
650 # # $a Yeast cell
700 0 # $a Agnes
700 0 # $a Anisa Kalondeng & Sulfahri
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